UC CORE

Navigation

• Target Nomination
  • Target Identification
    • Proteomics
    • Bioinformatics
    • Functional Genomics
    • Assay Development
    • Deep Sequencing
  • Target Validation
    • Functional Genomics
    • Proteomics
    • Assay Development
    • Compound Synthesis
    • Statistics and Data Mining
• Hit Generation
  • Compound Screening
    • High Throughput Screening (HTS)
    • High Content Screening
    • Data Mining of Screening Data
    • Computational Chemistry and Structural Biology
    • Fragment Based Screening
    • Compound Libraries
  • Hit Triage
    • Potency Determination
    • Purity Determination by LC-MS
    • Small Molecule NMR
    • Similarity Analysis
• Lead Optimization
  • Chemical
    • Compound Synthesis
    • Cheminformatics
  • Cellular and Molecular Pharmacology
    • Binding Affinity
    • Cellular Disease Models
    • Potency Determination
    • Selectivity Profiling
  • Drug Mode of Action Determination
    • Functional Genomics
    • Next Gen Sequencing
  • Cytotoxicity
    • Hepatotoxicity
    • Genotoxicity
    • Mitochondria Toxicity
  • Activity Testing
    • Potency Determination
    • Selectivity Profiling
  • Structural Biology
    • Crystallography, NMR – BioMolecule
    • Crystallography, NMR – Small Molecule
  • ADME
    • In Vitro Triage Studies
    • CYP Panel: Inhibition, Induction
    • In Vivo Pharmacokinatics (PK)
  • PK and PD Method Development
  • Toxicology
    • Mouse Toxicology: 7 and 21 day
    • Mouse Toxicology: Dose Finding
    • Blood Chemistry
  • Biomarkers
    • Assay Development
    • Proteomics
  • Efficacy Testing
    • In Vitro
    • In Vivo
• Preclinical Development
  • Non-GLP Safety Testing
    • Mouse Toxicology
    • 7 and 21 Day Studies
    • Dose Range Study
  • GLP Safety Testing (IND Enabled)
    • Biomarker Development
    • Mouse Toxicology
    • ADME
    • Initial Rodent pharmacokinetics (PK)
    • Pharmacodynamics (PD) Assay Development
  • Synthesis and Manufacturing
• Clinical Development
  • Document Preparation
  • Phase I
  • Phase II
  • Phase III