UC CORE

UC CORE
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  • Target Nomination
    • Target Identification
      • Proteomics
      • Bioinformatics
      • Functional Genomics
      • Assay Development
      • Deep Sequencing
    • Target Validation
      • Functional Genomics
      • Proteomics
      • Assay Development
      • Compound Synthesis
      • Statistics and Data Mining
  • Hit Generation
    • Compound Screening
      • High Throughput Screening (HTS)
      • High Content Screening
      • Data Mining of Screening Data
      • Computational Chemistry and Structural Biology
      • Fragment Based Screening
      • Compound Libraries
    • Hit Triage
      • Potency Determination
      • Purity Determination by LC-MS
      • Small Molecule NMR
      • Similarity Analysis
  • Lead Optimization
    • Chemical
      • Compound Synthesis
      • Cheminformatics
    • Cellular and Molecular Pharmacology
      • Binding Affinity
      • Cellular Disease Models
      • Potency Determination
      • Selectivity Profiling
    • Drug Mode of Action Determination
      • Functional Genomics
      • Next Gen Sequencing
    • Cytotoxicity
      • Hepatotoxicity
      • Genotoxicity
      • Mitochondria Toxicity
    • Activity Testing
      • Potency Determination
      • Selectivity Profiling
    • Structural Biology
      • Crystallography, NMR – BioMolecule
      • Crystallography, NMR – Small Molecule
    • ADME
      • In Vitro Triage Studies
      • CYP Panel: Inhibition, Induction
      • In Vivo Pharmacokinatics (PK)
    • PK and PD Method Development
    • Toxicology
      • Mouse Toxicology: 7 and 21 day
      • Mouse Toxicology: Dose Finding
      • Blood Chemistry
    • Biomarkers
      • Assay Development
      • Proteomics
    • Efficacy Testing
      • In Vitro
      • In Vivo
  • Preclinical Development
    • Non-GLP Safety Testing
      • Mouse Toxicology
      • 7 and 21 Day Studies
      • Dose Range Study
    • GLP Safety Testing (IND Enabled)
      • Biomarker Development
      • Mouse Toxicology
      • ADME
      • Initial Rodent pharmacokinetics (PK)
      • Pharmacodynamics (PD) Assay Development
    • Synthesis and Manufacturing
  • Clinical Development
    • Document Preparation
    • Phase I
    • Phase II
    • Phase III
  • Target Nomination
    • Target Identification
      • Proteomics
      • Bioinformatics
      • Functional Genomics
      • Assay Development
      • Deep Sequencing
    • Target Validation
      • Functional Genomics
      • Proteomics
      • Assay Development
      • Compound Synthesis
      • Statistics and Data Mining
  • Hit Generation
    • Compound Screening
      • High Throughput Screening (HTS)
      • High Content Screening
      • Data Mining of Screening Data
      • Computational Chemistry and Structural Biology
      • Fragment Based Screening
      • Compound Libraries
    • Hit Triage
      • Potency Determination
      • Purity Determination by LC-MS
      • Small Molecule NMR
      • Similarity Analysis
  • Lead Optimization
    • Chemical
      • Compound Synthesis
      • Cheminformatics
    • Cellular and Molecular Pharmacology
      • Binding Affinity
      • Cellular Disease Models
      • Potency Determination
      • Selectivity Profiling
    • Drug Mode of Action Determination
      • Functional Genomics
      • Next Gen Sequencing
    • Cytotoxicity
      • Hepatotoxicity
      • Genotoxicity
      • Mitochondria Toxicity
    • Activity Testing
      • Potency Determination
      • Selectivity Profiling
    • Structural Biology
      • Crystallography, NMR – BioMolecule
      • Crystallography, NMR – Small Molecule
    • ADME
      • In Vitro Triage Studies
      • CYP Panel: Inhibition, Induction
      • In Vivo Pharmacokinatics (PK)
    • PK and PD Method Development
    • Toxicology
      • Mouse Toxicology: 7 and 21 day
      • Mouse Toxicology: Dose Finding
      • Blood Chemistry
    • Biomarkers
      • Assay Development
      • Proteomics
    • Efficacy Testing
      • In Vitro
      • In Vivo
  • Preclinical Development
    • Non-GLP Safety Testing
      • Mouse Toxicology
      • 7 and 21 Day Studies
      • Dose Range Study
    • GLP Safety Testing (IND Enabled)
      • Biomarker Development
      • Mouse Toxicology
      • ADME
      • Initial Rodent pharmacokinetics (PK)
      • Pharmacodynamics (PD) Assay Development
    • Synthesis and Manufacturing
  • Clinical Development
    • Document Preparation
    • Phase I
    • Phase II
    • Phase III

Hit Generation

Early stage in drug discovery in which small molecules are identified from a high throughput screen as hit compounds.

UCSF Core Immunology laboratory/ CFAR Immunology Core

For over 21 years, the UCSF/CFAR Core Immunology Lab (CIL) has been dedicated to providing immunology assays, expert consultation, and education to the UCSF and global …

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