The UCSF Preclinical Therapeutics Core (PTC) facility generates tumor-bearing animals and conducts preclinical oncology trials for UCSF Helen Diller Family Comprehensive Cancer Center investigators. Offering a variety of xenograft and allograft-based cancer models, the core provides a complete set of services that include consultation regarding experimental design, tumor cell growth in culture, generation of tumors in mice, formulation and administration of experimental agents, monitoring of tumor burden and response to therapy, and preparation and interpretation of study results.
The BLI mission is to serve as the world's leading interdisciplinary center for Biomedical Optics by:
• Developing new, enabling biophotonic technologies
• Applying biophotonic technologies to important problems in biology and medicine
• Training students, fellows, and physicians in Biomedical Optics research
• Providing patients with access to advanced therapeutic and diagnostic clinical procedures using biophotonic medical devices
The Beckman Laser Institute (BLI) is a 37,000 square foot multi-disciplinary center for research, teaching, clinical medicine, and technology transfer located on the campus of the University of California, Irvine. The BLI is a division in the Department of Surgery in the School of Medicine and an important unit in the Department of Biomedical Engineering in the School of Engineering.
The In-Vivo Functional Onco-Imaging (IVFOI) shared resource supports basic and clinical cancer researchers by providing them with the necessary expertise, imaging instrumentation, and image analysis techniques.
NIC is a world-class facility, where we do cutting-edge research using state-of-the-art Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) scanners. Dr. Steven L. Small, Ph.D., M.D. was recently named Director of the Neuroscience Imaging Center. Because one in four families contains someone diagnosed with a debilitating brain disorder, it becomes imperative that physicians and researchers have effective tools for diagnosis, treatment evaluation, and understanding underlying mechanisms of brain pathology.
Understanding drug metabolism (DM), pharmacokinetics (PK), and pharmacodynamics (PD) is essential for the development of new therapeutics, which requires accurate and reliable quantification of drugs/metabolites in complex biological matrix. The PK/PD Bioanalytical Core Facility at UC Davis Medical Center (UCDMC) is equipped with a Waters Xevo TQS UPLC-MS/MS system and set up to provide state-of-the-art bioanalytical services to support the clinical and preclinical drug development programs
The mission of the Comparative Pathology Laboratory (CPL) is to provide laboratory animal biologists and basic discovery researchers the highest quality analytical data related to the health of their colony subjects, and projects requiring pre-clinical analysis. If you are in the business of managing research lab animal colonies, especially rodent species, we have a team that can address your questions regarding health monitoring, environment & equipment monitoring, phenotyping of custom bred strains, pathology services, clinical chemistry & hematology analysis related to compound discovery and efficacy.
The West Coast Metabolomics Center (WCMC), located at the University of California, is at the forefront of metabolomic innovation and service. We help researchers at UC Davis and extramural scientists with services, training and collaborative activities in biological and biomedical projects.
Provides in vitro and in vivo DMPK studies, including microsomal and hepatocyte metabolic stability; CYP inhibition and induction; pharmacokinetics; permeability; physicochemical characterization
GMP manufacturing facility
Manufacturing of GMP grade / clinical grade products for clinical trial applications
Manufacturing of biologics, cellular and gene therapies, gene therapy vectors and small molecule drug formulations
Regulatory consulting, CMC sections
Quality control on products
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The UCLA Pasarow Mass Spectrometry Laboratory is an intellectually vibrant group dedicated to the advancement of the science and training of students through innovative research and educational endeavors. As of January 2009 there are eight full-time members including two faculty, two senior technicians, two post docs, one Ph.D. students and one of undergraduate, in addition to numerous other UCLA faculty, staff and students who make frequent use of the facility and the in-house expertise. Our publication record is easily accessed via the web using Faull, KF and Whitelegge, JP as search descriptors. NSF and NIH Shared Instrument Grants over the past few years had led to the acquisition of several new instruments that complete the suite of available instrumentation. The availability of electron impact (EI), chemical (CI), atmospheric chemical ionization (APCI) and electrospray (ESI) ionization methods together in one facility is a feature of this Laboratory that is vital to the variety of chemical and biochemical research at UCLA. The Laboratory is also equipped a range of modern equipment necessary for the successful operation of a wet biochemical laboratory, including gas (capillary) and liquid chromatography (analytical, micro- and nano-bore) capability and gel electrophoresis.