The UCSF NMR Lab provides a range of state-of-the-art NMR facilities that are available for use by qualified academic and outside researchers. Besides experiments to identify and determine the structure of small organic molecules, the high-field NMR spectrometers (ranging from 400 to 800 MHz for 1H NMR) are capable of protein and RNA structure determination. This is accomplished via heteronuclear (e.g., 1H, 13C, 15N, 31P) multi-dimensional NMR spectra, often using locally written and widely distributed software (e.g., Sparky, MARDIGRAS, CORMA) for data analysis.
The Center for Advanced Technology (CAT) is a part of the Department of Biochemistry and Biophysics at the University of California, San Francisco. Our primary mission is to support research labs at UCSF through the resources that we host, but other academic and biotechnology organizations are welcome to use our facility through prior arrangements.
The SMDC collaborates with academics, government labs, and pharma companies to develop unique chemical probes and drug leads, using high-throughput screening, high-content imaging, fragment discovery, and medicinal chemistry. Data is accessed via the web using a home-build platform called HiTS.
Core Lab Website:
The BLI mission is to serve as the world's leading interdisciplinary center for Biomedical Optics by:
• Developing new, enabling biophotonic technologies
• Applying biophotonic technologies to important problems in biology and medicine
• Training students, fellows, and physicians in Biomedical Optics research
• Providing patients with access to advanced therapeutic and diagnostic clinical procedures using biophotonic medical devices
The Beckman Laser Institute (BLI) is a 37,000 square foot multi-disciplinary center for research, teaching, clinical medicine, and technology transfer located on the campus of the University of California, Irvine. The BLI is a division in the Department of Surgery in the School of Medicine and an important unit in the Department of Biomedical Engineering in the School of Engineering.
The Stem Cell Core Facility, a key component of the Sue and Bill Gross Stem Cell Research Center, provides stem cell technology and resources to the UCI, Orange County and Southern California research communities. These include developmental and molecular genetics, cell culture and cell sorting, imaging, high-throughput platforms, and bioinformatics.
The UCSD Screening Core provides infrastructure and consulting expertise for the development and implementation of screening assays in small, medium and high-throughput scale.
The Molecular Screening Shared Resource (MSSR) offers a comprehensive range of leading-edge high throughput screening (HTS) services including drug discovery, chemical and functional genomics, and novel methods for nano and environmental toxicology. The MSSR is an open access environment with investigators from UCLA as well as from the entire globe. Industrial clients are equally welcome as are non-profit entities.
The Embryonic Stem Cell/Transgenic Mice Shared Resource provides a multi-tiered service to accommodate individual investigators' needs in the production of transgenic mice, using pronuclear injection; targeted genetic alterations in embryonic stem (ES) cells and murine strains derived from ES cells with targeted mutations. The mission of the ES Cell/Transgenic Mice Shared Resource is to provide these services with high standards of quality control in a cost-effective manner. The ES Cell/Transgenic Mice Shared Resource provides advice to investigators in the design and assembly of DNA constructs, on the availability of transgenic animal models and for evaluating and implementing new methodologies as they arise. In addition to providing consulting services, the ES Cell/Transgenic Mice Shared Resource provides materials (expression vectors, quality-assured ES cells, batch-tested sera and reagents) to investigators opting to undertake these projects in their own laboratories. The ES Cell/Transgenic Mice Shared Resource has two facilities: in addition to providing advice and reagents, the ES Cell Culture Facility will perform electroporations and select and maintain targeted ES cell lines for individual investigators; and the Transgenic/KO Injection Facility of the shared resource performs pronuclear injections of DNA and blastocyst injections of targeted ES cells, and maintains transgenic animal lines in their initial stages.
Provides testing services, blood and blood cell products and other specialized services to research labs working with HIV and related viruses.