• The UCSF NMR Lab provides a range of state-of-the-art NMR facilities that are available for use by qualified academic and outside researchers. Besides experiments to identify and determine the structure of small organic molecules, the high-field NMR spectrometers (ranging from 400 to 800 MHz for 1H NMR) are capable of protein and RNA structure determination. This is accomplished via heteronuclear (e.g., 1H, 13C, 15N, 31P) multi-dimensional NMR spectra, often using locally written and widely distributed software (e.g., Sparky, MARDIGRAS, CORMA) for data analysis.

  • Provides high-precision, small-molecule structure determinations for organic and inorganic compounds for industry, academic and government laboratories. The laboratory is equipped with four state-of-the-art Bruker Single-Crystal Diffractometers with CCD detectors and low-temperature cryostats as well as a state-of-the-art Bruker Powder Diffractometer. Also, a library of graphical routines is available for all forms of data presentation. We can prepare and customize graphics for individual needs.

  • The purpose of the X-Ray Crystallography Facility is to structurally characterize single-crystal samples of organic, inorganic, and organometallic compounds using x-ray diffraction. The modern equipment provides researchers the ability to conduct rapid structural analysis. X-ray diffraction is often employed as the primary means of characterizing complex structures. Students, post-docs, and professors are encouraged to conduct their own experiments after a short training period.

  • The Nuclear Magnetic Resonance Spectroscopy Facility provides a non-destructive analytical technique to many research groups in the department and outside. NMR is primarily used for structural elucidation of organic and inorganic compounds. The facility is equipped with four Bruker Avance spectrometers: one 600 MHz, two 500 MHz, and one 400 MHz. One of the 500 MHz spectrometers is equipped with a highly sensitive cryoprobe. A separate 800 MHz NMR facility is available to all users for biomolecular NMR and other challenging problems.

  • Access to NMR technology for both UCSD and external users. Users can collect their own data, facility staff can do it all for you, or collaborative projects can be developed. The facility houses two 600 MHz Bruker Avance III spectrometers with cryogenically cooled probes for enhanced sensitivity. For samples whose concentration is limited by the amount of material available, or by solubility, our 1.7 mm microcoil cryoprobe requires just 40 μl of solution. We provide training in instrument operation and can offer advice for data analysis or project feasibility.

  • For more than 40 years the J.D. McCullough Laboratory of X-ray Crystallography has been in operation, providing 3-dimensional structure of small molecules in solid crystals via X-ray crystallography. The facility is also equipped for characterization of polycrystalline solid materials using powder and thin film diffraction techniques. The laboratory is a full service facility where staff deals with all aspects of service from crystal selection to publication of results. In-house training is a requirement if you wish to use the equipment yourself.

  • EICN can assist you in achieving success in your research by providing state-of-the-art electron microscopy instruments and assisted usage services. Highly experienced staff provides necessary training and can help users address complex electron imaging needs. EICN offers advanced electron imaging techniques for visualizing materials, nanomachines, and cellular structures at atomic or nanometer scales in 2D and 3D. In addition, our latest integrated iCorr technology enables a streamlined approach to correlative microscopy to perform both fluorescence light and electron microscopy for biological research.