Labs

  • The UCSF NMR Lab provides a range of state-of-the-art NMR facilities that are available for use by qualified academic and outside researchers. Besides experiments to identify and determine the structure of small organic molecules, the high-field NMR spectrometers (ranging from 400 to 800 MHz for 1H NMR) are capable of protein and RNA structure determination. This is accomplished via heteronuclear (e.g., 1H, 13C, 15N, 31P) multi-dimensional NMR spectra, often using locally written and widely distributed software (e.g., Sparky, MARDIGRAS, CORMA) for data analysis.

  • The Nuclear Magnetic Resonance Spectroscopy Facility provides a non-destructive analytical technique to many research groups in the department and outside. NMR is primarily used for structural elucidation of organic and inorganic compounds. The facility is equipped with four Bruker Avance spectrometers: one 600 MHz, two 500 MHz, and one 400 MHz. One of the 500 MHz spectrometers is equipped with a highly sensitive cryoprobe. A separate 800 MHz NMR facility is available to all users for biomolecular NMR and other challenging problems.

  • Featuring an 800 MHz NMR, EPR and Biacore SPR The 800 MHz NMR spectrometer (1394 Natural Sciences I) can detect proton, carbon and nitrogen signals and is equipped with hardware optimized for biomolecular applications. The Biacore 300 instrument (1304 Natural Sciences I) can measure docking interactions and binding affinity between biomolecules.
    http://www.research.uci.edu/facilities-services/shared-facilities/index....

  • Established in 2015, IMRI was built on the previous Laboratory for Electron and X-ray Instrumentation (LEXI) and newly established transmission electron microscopy (TEM) facilities. Today, IMRI operates a large number of open-access user facilities for the characterization of inorganic, organic, and biological materials and devices ranging from sub-Å to macroscopic length scales - available to all university, industry, and non-profit researchers.

  • Access to NMR technology for both UCSD and external users. Users can collect their own data, facility staff can do it all for you, or collaborative projects can be developed. The facility houses two 600 MHz Bruker Avance III spectrometers with cryogenically cooled probes for enhanced sensitivity. For samples whose concentration is limited by the amount of material available, or by solubility, our 1.7 mm microcoil cryoprobe requires just 40 μl of solution. We provide training in instrument operation and can offer advice for data analysis or project feasibility.

  • The UCLA Crystallization Facility provides state-of-the-art, high-throughput, crystallization services to all institutions. The full-service core offers access to sophisticated equipment and technologies, and technical assistance in sample preparation. The facility will provide screen preparation, plate setup, automated image acquisition and analysis, and optimization design. Our high-throughput set up can produce 18,000 experiments in a single day.

  • EICN can assist you in achieving success in your research by providing state-of-the-art electron microscopy instruments and assisted usage services. Highly experienced staff provides necessary training and can help users address complex electron imaging needs. EICN offers advanced electron imaging techniques for visualizing materials, nanomachines, and cellular structures at atomic or nanometer scales in 2D and 3D. In addition, our latest integrated iCorr technology enables a streamlined approach to correlative microscopy to perform both fluorescence light and electron microscopy for biological research.