Labs

  • The UCSF NMR Lab provides a range of state-of-the-art NMR facilities that are available for use by qualified academic and outside researchers. Besides experiments to identify and determine the structure of small organic molecules, the high-field NMR spectrometers (ranging from 400 to 800 MHz for 1H NMR) are capable of protein and RNA structure determination. This is accomplished via heteronuclear (e.g., 1H, 13C, 15N, 31P) multi-dimensional NMR spectra, often using locally written and widely distributed software (e.g., Sparky, MARDIGRAS, CORMA) for data analysis.

  • The UCSF Preclinical Therapeutics Core (PTC) facility generates tumor-bearing anima­­ls and conducts preclinical oncology trials for UCSF Helen Diller Family Comprehensive Cancer Center investigators. Offering a variety of xenograft and allograft-based cancer models, the core provides a complete set of services that include consultation regarding experimental design, tumor cell growth in culture, generation of tumors in mice, formulation and administration of experimental agents, monitoring of tumor burden and response to therapy, and preparation and interpretation of study results.

  • The Center for Advanced Technology (CAT) is a part of the Department of Biochemistry and Biophysics at the University of California, San Francisco. Our primary mission is to support research labs at UCSF through the resources that we host, but other academic and biotechnology organizations are welcome to use our facility through prior arrangements.

  • Gladstone Genomics Core provides services to support the next-generation sequencing needs of the scientific research community.

    Next-generation sequencing (NGS) experiments enable cutting-edge genomics, transcriptomics and epigenomics studies. We offer several types of library preparations for NGS, including quality control steps and sequencing, and we are constantly looking to expand our range of services with the latest techniques.

  • For over 21 years, the UCSF/CFAR Core Immunology Lab (CIL) has been dedicated to providing immunology assays, expert consultation, and education to the UCSF and global research community. CIL specializes in developing immunology research tools, and initiating and stimulating innovative research projects to address emerging questions in immunologic diseases including HIV pathogenesis.

  • The SMDC collaborates with academics, government labs, and pharma companies to develop unique chemical probes and drug leads, using high-throughput screening, high-content imaging, fragment discovery, and medicinal chemistry. Data is accessed via the web using a home-build platform called HiTS.

    Michelle Arkin
    michelle.arkin@ucsf.edu

    Core Lab Website:
    http://smdc.ucsf.edu/index.htm

  • We provide services to assist UCSF researchers in carrying out projects utilizing next generation sequencing approaches, including Illumina library preparation and bioinformatic analysis.

  • The Parnassus Flow Cytometry Core assists investigators whose research requires molecular marker characterization of cells in suspension as well as the isolation of cells based on those markers. Advanced cell sorting and cytometric analyses are readily conducted by experts within the Core or by trained laboratory members.

  • Provides high-precision, small-molecule structure determinations for organic and inorganic compounds for industry, academic and government laboratories. The laboratory is equipped with four state-of-the-art Bruker Single-Crystal Diffractometers with CCD detectors and low-temperature cryostats as well as a state-of-the-art Bruker Powder Diffractometer. Also, a library of graphical routines is available for all forms of data presentation. We can prepare and customize graphics for individual needs.

  • The purpose of the X-Ray Crystallography Facility is to structurally characterize single-crystal samples of organic, inorganic, and organometallic compounds using x-ray diffraction. The modern equipment provides researchers the ability to conduct rapid structural analysis. X-ray diffraction is often employed as the primary means of characterizing complex structures. Students, post-docs, and professors are encouraged to conduct their own experiments after a short training period.