The UCSF NMR Lab provides a range of state-of-the-art NMR facilities that are available for use by qualified academic and outside researchers. Besides experiments to identify and determine the structure of small organic molecules, the high-field NMR spectrometers (ranging from 400 to 800 MHz for 1H NMR) are capable of protein and RNA structure determination. This is accomplished via heteronuclear (e.g., 1H, 13C, 15N, 31P) multi-dimensional NMR spectra, often using locally written and widely distributed software (e.g., Sparky, MARDIGRAS, CORMA) for data analysis.
For over 21 years, the UCSF/CFAR Core Immunology Lab (CIL) has been dedicated to providing immunology assays, expert consultation, and education to the UCSF and global research community. CIL specializes in developing immunology research tools, and initiating and stimulating innovative research projects to address emerging questions in immunologic diseases including HIV pathogenesis.
The SMDC collaborates with academics, government labs, and pharma companies to develop unique chemical probes and drug leads, using high-throughput screening, high-content imaging, fragment discovery, and medicinal chemistry. Data is accessed via the web using a home-build platform called HiTS.
Core Lab Website:
The Parnassus Flow Cytometry Core assists investigators whose research requires molecular marker characterization of cells in suspension as well as the isolation of cells based on those markers. Advanced cell sorting and cytometric analyses are readily conducted by experts within the Core or by trained laboratory members.
The UCSD Screening Core provides infrastructure and consulting expertise for the development and implementation of screening assays in small, medium and high-throughput scale.
The Molecular Screening Shared Resource (MSSR) offers a comprehensive range of leading-edge high throughput screening (HTS) services including drug discovery, chemical and functional genomics, and novel methods for nano and environmental toxicology. The MSSR is an open access environment with investigators from UCLA as well as from the entire globe. Industrial clients are equally welcome as are non-profit entities.
The Mitochondria and Metabolism Core at UCLA provides the scientific community with the necessary technical and conceptual resources for studying mitochondrial function. We provide access to Seahorse XF96 Extracellular Flux Analyzers and an Operetta High Content Imager, which users can schedule after training. Additionally, The Mitochondria Core provides a number of full service options for the design, performance, analysis and interpretation of fundamental mitochondrial assays.
Orian Shirihai, MD PhD