The UCSF NMR Lab provides a range of state-of-the-art NMR facilities that are available for use by qualified academic and outside researchers. Besides experiments to identify and determine the structure of small organic molecules, the high-field NMR spectrometers (ranging from 400 to 800 MHz for 1H NMR) are capable of protein and RNA structure determination. This is accomplished via heteronuclear (e.g., 1H, 13C, 15N, 31P) multi-dimensional NMR spectra, often using locally written and widely distributed software (e.g., Sparky, MARDIGRAS, CORMA) for data analysis.
The mission of the UCLA X-ray Crystallography Core Facility is to provide state-of-the-art resources to researchers at UCLA., enabling the detailed 3-D analysis of biological macromolecules that play essential roles in human health. The facility operates as a full service core that not only offers access to sophisticated equipment and technologies, but also offers advice and technical assitance in sample preparation, data collection, processing, atomic refinement and modeling.
The purpose of the X-ray Crystallography Core Facility is to provide equipment, training, assistance, and technological innovation for determining 3D atomic structures of proteins and other macromolecules.
The X-ray Facility conducts original research in developing and improving crystallographic tools, and helps scientists determine atomic structures. Each structure determined using the Facility not only yields insight into biochemical pathways, but also expands databases used for improving algorithms for fold assignment, structure verification, atomic refinement, potential energy functions, and analysis of protein-protein interactions.
The Molecular Screening Shared Resource (MSSR) offers a comprehensive range of leading-edge high throughput screening (HTS) services including drug discovery, chemical and functional genomics, and novel methods for nano and environmental toxicology. The MSSR is an open access environment with investigators from UCLA as well as from the entire globe. Industrial clients are equally welcome as are non-profit entities.
The UCLA Crystallization Facility provides state-of-the-art, high-throughput, crystallization services to all institutions. The full-service core offers access to sophisticated equipment and technologies, and technical assistance in sample preparation. The facility will provide screen preparation, plate setup, automated image acquisition and analysis, and optimization design. Our high-throughput set up can produce 18,000 experiments in a single day.