Labs

  • The UCSF NMR Lab provides a range of state-of-the-art NMR facilities that are available for use by qualified academic and outside researchers. Besides experiments to identify and determine the structure of small organic molecules, the high-field NMR spectrometers (ranging from 400 to 800 MHz for 1H NMR) are capable of protein and RNA structure determination. This is accomplished via heteronuclear (e.g., 1H, 13C, 15N, 31P) multi-dimensional NMR spectra, often using locally written and widely distributed software (e.g., Sparky, MARDIGRAS, CORMA) for data analysis.

  • For over 21 years, the UCSF/CFAR Core Immunology Lab (CIL) has been dedicated to providing immunology assays, expert consultation, and education to the UCSF and global research community. CIL specializes in developing immunology research tools, and initiating and stimulating innovative research projects to address emerging questions in immunologic diseases including HIV pathogenesis.

  • The SMDC collaborates with academics, government labs, and pharma companies to develop unique chemical probes and drug leads, using high-throughput screening, high-content imaging, fragment discovery, and medicinal chemistry. Data is accessed via the web using a home-build platform called HiTS.

    Michelle Arkin
    michelle.arkin@ucsf.edu

    Core Lab Website:
    http://smdc.ucsf.edu/index.htm

  • The Laboratory for Cell Analysis provides cytometric, microscopic, and genomic support and services for the UCSF Helen Diller Family Comprehensive Cancer Center. The LCA was established in 1983 with the following responsibilities:

  • The Parnassus Flow Cytometry Core assists investigators whose research requires molecular marker characterization of cells in suspension as well as the isolation of cells based on those markers. Advanced cell sorting and cytometric analyses are readily conducted by experts within the Core or by trained laboratory members.

  • The Optical Biology Core (OBC) operates under the theme that technology enables discovery. Consequently, the goal of the OBC is to provide the best conventional microscopy platforms available and to develop and introduce novel optical methods that allow new discoveries to be made.

  • The facility incorporates a variety of pulsed and continuous wave laser systems. In general, our pulsed laser systems are tunable through the use of optical parametric oscillators. We also operate and maintain tools for Raman microscopy and conventional linear and non-linear spectroscopy applications. We offer assistance in data acquisition, analysis and discussion. Consultation services spanning the wide range of disciplines including linear and nonlinear spectroscopy, ultrafast phenomena and light-matter interactions. Circular Dichroism is also available in this facility.

  • The Laboratory for Fluorescence Dynamics (LFD) is a national research resource center for biomedical fluorescence spectroscopy, supported by the National Center for Research Resources (NCRR, 5P41RR003155) and the National Institute of General Medical Sciences (NIGMS, 8P41GM103540) divisions of the National Institutes of Health (NIH) and the University of California, Irvine (UCI). The founder and Principal Investigator of the LFD is Enrico Gratton. The Co-Investigator is Michelle Digman.

  • The Laser Microbeam and Medical Program (LAMMP), is dedicated to the use of lasers and optics in Biology and Medicine. LAMMP is located within the Beckman Laser Institute and Medical Clinic, an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. LAMMP activities span from basic science and technology development to clinical translational research.

  • The Transgenic Mouse Facility (TMF) facilitates the use of genetically modi¬fied mice in biological and biomedical research. An important goal of the TMF is to identify new technology and methodology that is likely to benefi¬t UC Irvine investigators using the mouse in their research programs and to import and provide such technology to UC Irvine investigators. The TMF makes investigators aware of new and existing developments via the TMF website, in seminars and lectures, via the UC Irvine MouseUsers email list and by word of mouth.